Variability in the Analgesic Response to Ibuprofen Is Associated With Cyclooxygenase Activation in Inflammatory Pain

The mechanisms underlying interindividual variability in analgesic efficacy of nonsteroidal anti‐inflammatory drugs (NSAIDs) are not well understood. Therefore, we performed pain phenotyping, functional neuroimaging, pharmacokinetic/pharmacodynamic assessments, inflammation biomarkers, and gene expr...

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Detalles Bibliográficos
Autores principales: Theken, Katherine N., Hersh, Elliot V., Lahens, Nicholas F., Lee, Hyo Min, Li, Xuanwen, Granquist, Eric J., Giannakopoulos, Helen E., Levin, Lawrence M., Secreto, Stacey A., Grant, Gregory R., Detre, John A., FitzGerald, Garret A., Grosser, Tilo, Farrar, John T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753944/
https://www.ncbi.nlm.nih.gov/pubmed/30929268
http://dx.doi.org/10.1002/cpt.1446

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