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Uveitis Therapy With Shark Variable Novel Antigen Receptor Domains Targeting Tumor Necrosis Factor Alpha or Inducible T-Cell Costimulatory Ligand

PURPOSE: We assess the efficacy of two next-generation biologic therapies in treating experimental autoimmune uveitis. METHODS: Variable binding domains from shark immunoglobulin novel antigen receptors (VNARs) were fused with a mouse IgG2a constant domain (Fc) to generate VNAR-Fc molecules with bin...

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Detalles Bibliográficos
Autores principales:	Pepple, Kathryn L., Wilson, Leslie, Van Gelder, Russell N., Kovaleva, Marina, Ubah, Obinna C., Steven, John, Barelle, Caroline J., Porter, Andrew
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2019
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753974/ https://www.ncbi.nlm.nih.gov/pubmed/31588375 http://dx.doi.org/10.1167/tvst.8.5.11

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