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Tissue conservation for transplantation
Pathophysiological changes that occur during ischemia and subsequent reperfusion cause damage to tissues procured for transplantation and also affect long-term allograft function and survival. The proper preservation of organs before transplantation is a must to limit these injuries as much as possi...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
De Gruyter
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754021/ https://www.ncbi.nlm.nih.gov/pubmed/31579751 http://dx.doi.org/10.1515/iss-2017-0010 |
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author | Krezdorn, Nicco Tasigiorgos, Sotirios Wo, Luccie Turk, Marvee Lopdrup, Rachel Kiwanuka, Harriet Win, Thet-Su Bueno, Ericka Pomahac, Bohdan |
author_facet | Krezdorn, Nicco Tasigiorgos, Sotirios Wo, Luccie Turk, Marvee Lopdrup, Rachel Kiwanuka, Harriet Win, Thet-Su Bueno, Ericka Pomahac, Bohdan |
author_sort | Krezdorn, Nicco |
collection | PubMed |
description | Pathophysiological changes that occur during ischemia and subsequent reperfusion cause damage to tissues procured for transplantation and also affect long-term allograft function and survival. The proper preservation of organs before transplantation is a must to limit these injuries as much as possible. For decades, static cold storage has been the gold standard for organ preservation, with mechanical perfusion developing as a promising alternative only recently. The current literature points to the need of developing dedicated preservation protocols for every organ, which in combination with other interventions such as ischemic preconditioning and therapeutic additives offer the possibility of improving organ preservation and extending it to multiple times its current duration. This review strives to present an overview of the current body of knowledge with regard to the preservation of organs and tissues destined for transplantation. |
format | Online Article Text |
id | pubmed-6754021 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | De Gruyter |
record_format | MEDLINE/PubMed |
spelling | pubmed-67540212019-10-02 Tissue conservation for transplantation Krezdorn, Nicco Tasigiorgos, Sotirios Wo, Luccie Turk, Marvee Lopdrup, Rachel Kiwanuka, Harriet Win, Thet-Su Bueno, Ericka Pomahac, Bohdan Innov Surg Sci Reviews Pathophysiological changes that occur during ischemia and subsequent reperfusion cause damage to tissues procured for transplantation and also affect long-term allograft function and survival. The proper preservation of organs before transplantation is a must to limit these injuries as much as possible. For decades, static cold storage has been the gold standard for organ preservation, with mechanical perfusion developing as a promising alternative only recently. The current literature points to the need of developing dedicated preservation protocols for every organ, which in combination with other interventions such as ischemic preconditioning and therapeutic additives offer the possibility of improving organ preservation and extending it to multiple times its current duration. This review strives to present an overview of the current body of knowledge with regard to the preservation of organs and tissues destined for transplantation. De Gruyter 2017-08-08 /pmc/articles/PMC6754021/ /pubmed/31579751 http://dx.doi.org/10.1515/iss-2017-0010 Text en ©2017 Krezdorn N. et al., published by De Gruyter, Berlin/Boston http://creativecommons.org/licenses/by-nc-nd/4.0 This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. |
spellingShingle | Reviews Krezdorn, Nicco Tasigiorgos, Sotirios Wo, Luccie Turk, Marvee Lopdrup, Rachel Kiwanuka, Harriet Win, Thet-Su Bueno, Ericka Pomahac, Bohdan Tissue conservation for transplantation |
title | Tissue conservation for transplantation |
title_full | Tissue conservation for transplantation |
title_fullStr | Tissue conservation for transplantation |
title_full_unstemmed | Tissue conservation for transplantation |
title_short | Tissue conservation for transplantation |
title_sort | tissue conservation for transplantation |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754021/ https://www.ncbi.nlm.nih.gov/pubmed/31579751 http://dx.doi.org/10.1515/iss-2017-0010 |
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