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Neurocognitive Performance Deficits Related to Immediate and Acute Blast Overpressure Exposure

Addressing the concerns surrounding blast injury for the military community is a pressing matter. Specifically, sub-concussive blast effects, or those blast effects which do not yield a medical diagnosis but can result in symptom reporting and negative self-reported outcomes, are becoming increasing...

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Autores principales: LaValle, Christina R., Carr, Walter S., Egnoto, Michael J., Misistia, Anthony C., Salib, Jonathan E., Ramos, Alejandro N., Kamimori, Gary H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754066/
https://www.ncbi.nlm.nih.gov/pubmed/31572285
http://dx.doi.org/10.3389/fneur.2019.00949
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author LaValle, Christina R.
Carr, Walter S.
Egnoto, Michael J.
Misistia, Anthony C.
Salib, Jonathan E.
Ramos, Alejandro N.
Kamimori, Gary H.
author_facet LaValle, Christina R.
Carr, Walter S.
Egnoto, Michael J.
Misistia, Anthony C.
Salib, Jonathan E.
Ramos, Alejandro N.
Kamimori, Gary H.
author_sort LaValle, Christina R.
collection PubMed
description Addressing the concerns surrounding blast injury for the military community is a pressing matter. Specifically, sub-concussive blast effects, or those blast effects which do not yield a medical diagnosis but can result in symptom reporting and negative self-reported outcomes, are becoming increasingly important. This work evaluates explosive blast overpressure and impulse effects at the sub-concussive level on neurocognitive performance assessed with the Defense Automated Neurobehavioral Assessment (DANA) across seven breacher training courses conducted by the US Military. The results reported here come from 202 healthy, male military volunteer participants. Findings indicate that the neurocognitive task appearing most sensitive to identifying performance change is the DANA Procedural Reaction Time (PRT) subtask which may involve a sufficient level of challenge to reliably detect a small, transient cognitive impairment among a healthy undiagnosed population. The blast characteristic that was consistently associated with performance change was peak overpressure. Overall, this study provides evidence that increasing blast overpressure, defined as peak overpressure experienced in a training day, can lead to transient degradations in neurocognitive performance as seen on the DANA PRT subtask, which may generalize to other capabilities.
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spelling pubmed-67540662019-09-30 Neurocognitive Performance Deficits Related to Immediate and Acute Blast Overpressure Exposure LaValle, Christina R. Carr, Walter S. Egnoto, Michael J. Misistia, Anthony C. Salib, Jonathan E. Ramos, Alejandro N. Kamimori, Gary H. Front Neurol Neurology Addressing the concerns surrounding blast injury for the military community is a pressing matter. Specifically, sub-concussive blast effects, or those blast effects which do not yield a medical diagnosis but can result in symptom reporting and negative self-reported outcomes, are becoming increasingly important. This work evaluates explosive blast overpressure and impulse effects at the sub-concussive level on neurocognitive performance assessed with the Defense Automated Neurobehavioral Assessment (DANA) across seven breacher training courses conducted by the US Military. The results reported here come from 202 healthy, male military volunteer participants. Findings indicate that the neurocognitive task appearing most sensitive to identifying performance change is the DANA Procedural Reaction Time (PRT) subtask which may involve a sufficient level of challenge to reliably detect a small, transient cognitive impairment among a healthy undiagnosed population. The blast characteristic that was consistently associated with performance change was peak overpressure. Overall, this study provides evidence that increasing blast overpressure, defined as peak overpressure experienced in a training day, can lead to transient degradations in neurocognitive performance as seen on the DANA PRT subtask, which may generalize to other capabilities. Frontiers Media S.A. 2019-09-13 /pmc/articles/PMC6754066/ /pubmed/31572285 http://dx.doi.org/10.3389/fneur.2019.00949 Text en Copyright © 2019 LaValle, Carr, Egnoto, Misistia, Salib, Ramos and Kamimori. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
LaValle, Christina R.
Carr, Walter S.
Egnoto, Michael J.
Misistia, Anthony C.
Salib, Jonathan E.
Ramos, Alejandro N.
Kamimori, Gary H.
Neurocognitive Performance Deficits Related to Immediate and Acute Blast Overpressure Exposure
title Neurocognitive Performance Deficits Related to Immediate and Acute Blast Overpressure Exposure
title_full Neurocognitive Performance Deficits Related to Immediate and Acute Blast Overpressure Exposure
title_fullStr Neurocognitive Performance Deficits Related to Immediate and Acute Blast Overpressure Exposure
title_full_unstemmed Neurocognitive Performance Deficits Related to Immediate and Acute Blast Overpressure Exposure
title_short Neurocognitive Performance Deficits Related to Immediate and Acute Blast Overpressure Exposure
title_sort neurocognitive performance deficits related to immediate and acute blast overpressure exposure
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754066/
https://www.ncbi.nlm.nih.gov/pubmed/31572285
http://dx.doi.org/10.3389/fneur.2019.00949
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