Ultra-High-Frequency Reprogramming of Individual Long-Term Hematopoietic Stem Cells Yields Low Somatic Variant Induced Pluripotent Stem Cells

Efficiency of reprogramming of human cells into induced pluripotent stem cells (iPSCs) has remained low. We report that individual adult human CD49f(+) long-term hematopoietic stem cells (LT-HSCs) can be reprogrammed into iPSCs at close to 50% efficiency using Sendai virus transduction. This exquisi...

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Detalles Bibliográficos
Autores principales: Wang, Kai, Guzman, Anthony K., Yan, Zi, Zhang, Shouping, Hu, Michael Y., Hamaneh, Mehdi B., Yu, Yi-Kuo, Tolu, Seda, Zhang, Jinghang, Kanavy, Holly E., Ye, Kenny, Bartholdy, Boris, Bouhassira, Eric E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754097/
https://www.ncbi.nlm.nih.gov/pubmed/30840883
http://dx.doi.org/10.1016/j.celrep.2019.02.021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754097/
https://www.ncbi.nlm.nih.gov/pubmed/30840883
http://dx.doi.org/10.1016/j.celrep.2019.02.021

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