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Targeted homology-directed repair in blood stem and progenitor cells with CRISPR nanoformulations

Ex vivo CRISPR gene editing in hematopoietic stem and progenitor cells has opened potential treatment modalities for numerous diseases. The current process uses electroporation, sometimes followed by virus transduction. While this complex manipulation has resulted in high levels of gene editing at s...

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Detalles Bibliográficos
Autores principales: Shahbazi, Reza, Sghia-Hughes, Gabriella, Reid, Jack L., Kubek, Sara, Haworth, Kevin G., Humbert, Olivier, Kiem, Hans-Peter, Adair, Jennifer E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754292/
https://www.ncbi.nlm.nih.gov/pubmed/31133730
http://dx.doi.org/10.1038/s41563-019-0385-5

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