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PTPN2 regulates the generation of exhausted CD8(+) T cell subpopulations and restrains tumor immunity

CD8(+) T cell exhaustion is a state of dysfunction acquired in chronic viral infection and cancer, characterized by the formation of Slamf6(+) progenitor exhausted and Tim-3(+) terminally exhausted subpopulations through unknown mechanisms. Here we establish the phosphatase PTPN2 as a novel regulato...

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Detalles Bibliográficos
Autores principales:	LaFleur, Martin W., Nguyen, Thao H., Coxe, Matthew A., Miller, Brian C., Yates, Kathleen B., Gillis, Jacob E., Sen, Debattama R., Gaudiano, Emily F., Abosy, Rose Al, Freeman, Gordon J., Haining, W. Nicholas, Sharpe, Arlene H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754306/ https://www.ncbi.nlm.nih.gov/pubmed/31527834 http://dx.doi.org/10.1038/s41590-019-0480-4

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