CRISPR/Cas9 knockout of USP18 enhances type I IFN responsiveness and restricts HIV‐1 infection in macrophages

The IFN‐stimulated gene ubiquitin‐specific proteinase 18 (USP18) encodes a protein that negatively regulates T1 IFN signaling via stearic inhibition of JAK1 recruitment to the IFN‐α receptor 2 subunit (IFNAR2). Here, we demonstrate that USP18 expression is induced by HIV‐1 in a T1 IFN‐dependent mann...

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Detalles Bibliográficos
Autores principales: Taylor, Jared P., Cash, Melanie N., Santostefano, Katherine E., Nakanishi, Mahito, Terada, Naohiro, Wallet, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Special Focus Issue
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754309/
https://www.ncbi.nlm.nih.gov/pubmed/29437254
http://dx.doi.org/10.1002/JLB.3MIA0917-352R

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754309/
https://www.ncbi.nlm.nih.gov/pubmed/29437254
http://dx.doi.org/10.1002/JLB.3MIA0917-352R

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