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CRISPR/Cas9 knockout of USP18 enhances type I IFN responsiveness and restricts HIV‐1 infection in macrophages

The IFN‐stimulated gene ubiquitin‐specific proteinase 18 (USP18) encodes a protein that negatively regulates T1 IFN signaling via stearic inhibition of JAK1 recruitment to the IFN‐α receptor 2 subunit (IFNAR2). Here, we demonstrate that USP18 expression is induced by HIV‐1 in a T1 IFN‐dependent mann...

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Detalles Bibliográficos
Autores principales:	Taylor, Jared P., Cash, Melanie N., Santostefano, Katherine E., Nakanishi, Mahito, Terada, Naohiro, Wallet, Mark A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Special Focus Issue
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754309/ https://www.ncbi.nlm.nih.gov/pubmed/29437254 http://dx.doi.org/10.1002/JLB.3MIA0917-352R

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