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Structure of full-length wild-type human phenylalanine hydroxylase by small angle X-ray scattering reveals substrate-induced conformational stability

Human phenylalanine hydroxylase (hPAH) hydroxylates l-phenylalanine (l-Phe) to l-tyrosine, a precursor for neurotransmitter biosynthesis. Phenylketonuria (PKU), caused by mutations in PAH that impair PAH function, leads to neurological impairment when untreated. Understanding the hPAH structural and...

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Detalles Bibliográficos
Autores principales:	Tomé, Catarina S., Lopes, Raquel R., Sousa, Pedro M. F., Amaro, Mariana P., Leandro, João, Mertens, Haydyn D. T., Leandro, Paula, Vicente, João B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754429/ https://www.ncbi.nlm.nih.gov/pubmed/31541188 http://dx.doi.org/10.1038/s41598-019-49944-x

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