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Structure of Csx1-cOA(4) complex reveals the basis of RNA decay in Type III-B CRISPR-Cas

Type III CRISPR-Cas multisubunit complexes cleave ssRNA and ssDNA. These activities promote the generation of cyclic oligoadenylate (cOA), which activates associated CRISPR-Cas RNases from the Csm/Csx families, triggering a massive RNA decay to provide immunity from genetic invaders. Here we present...

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Detalles Bibliográficos
Autores principales:	Molina, Rafael, Stella, Stefano, Feng, Mingxia, Sofos, Nicholas, Jauniskis, Vykintas, Pozdnyakova, Irina, López-Méndez, Blanca, She, Qunxin, Montoya, Guillermo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754442/ https://www.ncbi.nlm.nih.gov/pubmed/31541109 http://dx.doi.org/10.1038/s41467-019-12244-z

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