Cargando…

Spontaneous shrinking of soft nanoparticles boosts their diffusion in confined media

Improving nanoparticles (NPs) transport across biological barriers is a significant challenge that could be addressed through understanding NPs diffusion in dense and confined media. Here, we report the ability of soft NPs to shrink in confined environments, therefore boosting their diffusion compar...

Descripción completa

Detalles Bibliográficos
Autores principales: Latreille, Pierre-Luc, Adibnia, Vahid, Nour, Antone, Rabanel, Jean-Michel, Lalloz, Augustine, Arlt, Jochen, Poon, Wilson C. K., Hildgen, Patrice, Martinez, Vincent A., Banquy, Xavier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754464/
https://www.ncbi.nlm.nih.gov/pubmed/31541104
http://dx.doi.org/10.1038/s41467-019-12246-x
_version_ 1783453083031830528
author Latreille, Pierre-Luc
Adibnia, Vahid
Nour, Antone
Rabanel, Jean-Michel
Lalloz, Augustine
Arlt, Jochen
Poon, Wilson C. K.
Hildgen, Patrice
Martinez, Vincent A.
Banquy, Xavier
author_facet Latreille, Pierre-Luc
Adibnia, Vahid
Nour, Antone
Rabanel, Jean-Michel
Lalloz, Augustine
Arlt, Jochen
Poon, Wilson C. K.
Hildgen, Patrice
Martinez, Vincent A.
Banquy, Xavier
author_sort Latreille, Pierre-Luc
collection PubMed
description Improving nanoparticles (NPs) transport across biological barriers is a significant challenge that could be addressed through understanding NPs diffusion in dense and confined media. Here, we report the ability of soft NPs to shrink in confined environments, therefore boosting their diffusion compared to hard, non-deformable particles. We demonstrate this behavior by embedding microgel NPs in agarose gels. The origin of the shrinking appears to be related to the overlap of the electrostatic double layers (EDL) surrounding the NPs and the agarose fibres. Indeed, it is shown that screening the EDL interactions, by increasing the ionic strength of the medium, prevents the soft particle shrinkage. The shrunken NPs diffuse up to 2 orders of magnitude faster in agarose gel than their hard NP counterparts. These findings provide valuable insights on the role of long range interactions on soft NPs dynamics in crowded environments, and help rationalize the design of more efficient NP-based transport systems.
format Online
Article
Text
id pubmed-6754464
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-67544642019-09-23 Spontaneous shrinking of soft nanoparticles boosts their diffusion in confined media Latreille, Pierre-Luc Adibnia, Vahid Nour, Antone Rabanel, Jean-Michel Lalloz, Augustine Arlt, Jochen Poon, Wilson C. K. Hildgen, Patrice Martinez, Vincent A. Banquy, Xavier Nat Commun Article Improving nanoparticles (NPs) transport across biological barriers is a significant challenge that could be addressed through understanding NPs diffusion in dense and confined media. Here, we report the ability of soft NPs to shrink in confined environments, therefore boosting their diffusion compared to hard, non-deformable particles. We demonstrate this behavior by embedding microgel NPs in agarose gels. The origin of the shrinking appears to be related to the overlap of the electrostatic double layers (EDL) surrounding the NPs and the agarose fibres. Indeed, it is shown that screening the EDL interactions, by increasing the ionic strength of the medium, prevents the soft particle shrinkage. The shrunken NPs diffuse up to 2 orders of magnitude faster in agarose gel than their hard NP counterparts. These findings provide valuable insights on the role of long range interactions on soft NPs dynamics in crowded environments, and help rationalize the design of more efficient NP-based transport systems. Nature Publishing Group UK 2019-09-20 /pmc/articles/PMC6754464/ /pubmed/31541104 http://dx.doi.org/10.1038/s41467-019-12246-x Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Latreille, Pierre-Luc
Adibnia, Vahid
Nour, Antone
Rabanel, Jean-Michel
Lalloz, Augustine
Arlt, Jochen
Poon, Wilson C. K.
Hildgen, Patrice
Martinez, Vincent A.
Banquy, Xavier
Spontaneous shrinking of soft nanoparticles boosts their diffusion in confined media
title Spontaneous shrinking of soft nanoparticles boosts their diffusion in confined media
title_full Spontaneous shrinking of soft nanoparticles boosts their diffusion in confined media
title_fullStr Spontaneous shrinking of soft nanoparticles boosts their diffusion in confined media
title_full_unstemmed Spontaneous shrinking of soft nanoparticles boosts their diffusion in confined media
title_short Spontaneous shrinking of soft nanoparticles boosts their diffusion in confined media
title_sort spontaneous shrinking of soft nanoparticles boosts their diffusion in confined media
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754464/
https://www.ncbi.nlm.nih.gov/pubmed/31541104
http://dx.doi.org/10.1038/s41467-019-12246-x
work_keys_str_mv AT latreillepierreluc spontaneousshrinkingofsoftnanoparticlesbooststheirdiffusioninconfinedmedia
AT adibniavahid spontaneousshrinkingofsoftnanoparticlesbooststheirdiffusioninconfinedmedia
AT nourantone spontaneousshrinkingofsoftnanoparticlesbooststheirdiffusioninconfinedmedia
AT rabaneljeanmichel spontaneousshrinkingofsoftnanoparticlesbooststheirdiffusioninconfinedmedia
AT lallozaugustine spontaneousshrinkingofsoftnanoparticlesbooststheirdiffusioninconfinedmedia
AT arltjochen spontaneousshrinkingofsoftnanoparticlesbooststheirdiffusioninconfinedmedia
AT poonwilsonck spontaneousshrinkingofsoftnanoparticlesbooststheirdiffusioninconfinedmedia
AT hildgenpatrice spontaneousshrinkingofsoftnanoparticlesbooststheirdiffusioninconfinedmedia
AT martinezvincenta spontaneousshrinkingofsoftnanoparticlesbooststheirdiffusioninconfinedmedia
AT banquyxavier spontaneousshrinkingofsoftnanoparticlesbooststheirdiffusioninconfinedmedia