TNFR2 induced priming of the inflammasome leads to a RIPK1-dependent cell death in the absence of XIAP

The pediatric immune deficiency X-linked proliferative disease-2 (XLP-2) is a unique disease, with patients presenting with either hemophagocytic lymphohistiocytosis (HLH) or intestinal bowel disease (IBD). Interestingly, XLP-2 patients display high levels of IL-18 in the serum even while in stable...

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Detalles Bibliográficos
Autores principales: Knop, Janin, Spilgies, Lisanne M., Rufli, Stefanie, Reinhart, Ramona, Vasilikos, Lazaros, Yabal, Monica, Owsley, Erika, Jost, Philipp J., Marsh, Rebecca A., Wajant, Harald, Robinson, Mark D., Kaufmann, Thomas, Wong, W. Wei-Lynn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754467/
https://www.ncbi.nlm.nih.gov/pubmed/31541082
http://dx.doi.org/10.1038/s41419-019-1938-x

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