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Leveraging protein dynamics to identify cancer mutational hotspots using 3D structures
Large-scale exome sequencing of tumors has enabled the identification of cancer drivers using recurrence-based approaches. Some of these methods also employ 3D protein structures to identify mutational hotspots in cancer-associated genes. In determining such mutational clusters in structures, existi...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754584/ https://www.ncbi.nlm.nih.gov/pubmed/31462496 http://dx.doi.org/10.1073/pnas.1901156116 |