Focal segmental glomerulosclerosis in which urinary protein improved after surgical treatment for acromegaly: a case report

BACKGROUND: Focal segmental glomerulosclerosis is characterized by partial (segmental) sclerotic lesions in some glomeruli (focal). Primary focal segmental glomerulosclerosis is generally considered resistant to steroid therapy. However, acromegaly is a disease that causes peculiar facial features,...

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Autores principales: Yamasaki, Arina, Bito, Daisuke, Eto, Erina, Matsumoto, Keiichiro, Nakamura, Megumi, Miyazaki, Junji, Matsumoto, Kenichi, Masuda, Masanori, Mori, Daisuke, Yoshimura, Toru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754629/
https://www.ncbi.nlm.nih.gov/pubmed/31540583
http://dx.doi.org/10.1186/s13256-019-2228-z
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author Yamasaki, Arina
Bito, Daisuke
Eto, Erina
Matsumoto, Keiichiro
Nakamura, Megumi
Miyazaki, Junji
Matsumoto, Kenichi
Masuda, Masanori
Mori, Daisuke
Yoshimura, Toru
author_facet Yamasaki, Arina
Bito, Daisuke
Eto, Erina
Matsumoto, Keiichiro
Nakamura, Megumi
Miyazaki, Junji
Matsumoto, Kenichi
Masuda, Masanori
Mori, Daisuke
Yoshimura, Toru
author_sort Yamasaki, Arina
collection PubMed
description BACKGROUND: Focal segmental glomerulosclerosis is characterized by partial (segmental) sclerotic lesions in some glomeruli (focal). Primary focal segmental glomerulosclerosis is generally considered resistant to steroid therapy. However, acromegaly is a disease that causes peculiar facial features, body types, and metabolic abnormalities due to the excessive secretion of growth hormone by a pituitary adenoma. Growth hormone has been reported to be involved in glomerular cell growth, mesangial proliferation, and glomerulosclerosis in the kidney. CASE PRESENTATION: We report a case of a Japanese patient with focal segmental glomerulosclerosis in whom decreased urinary protein was observed after surgical treatment for acromegaly. CONCLUSION: The patient’s urinary protein improved as the concentration of growth hormone/insulin-like growth factor 1 decreased.
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spelling pubmed-67546292019-09-26 Focal segmental glomerulosclerosis in which urinary protein improved after surgical treatment for acromegaly: a case report Yamasaki, Arina Bito, Daisuke Eto, Erina Matsumoto, Keiichiro Nakamura, Megumi Miyazaki, Junji Matsumoto, Kenichi Masuda, Masanori Mori, Daisuke Yoshimura, Toru J Med Case Rep Case Report BACKGROUND: Focal segmental glomerulosclerosis is characterized by partial (segmental) sclerotic lesions in some glomeruli (focal). Primary focal segmental glomerulosclerosis is generally considered resistant to steroid therapy. However, acromegaly is a disease that causes peculiar facial features, body types, and metabolic abnormalities due to the excessive secretion of growth hormone by a pituitary adenoma. Growth hormone has been reported to be involved in glomerular cell growth, mesangial proliferation, and glomerulosclerosis in the kidney. CASE PRESENTATION: We report a case of a Japanese patient with focal segmental glomerulosclerosis in whom decreased urinary protein was observed after surgical treatment for acromegaly. CONCLUSION: The patient’s urinary protein improved as the concentration of growth hormone/insulin-like growth factor 1 decreased. BioMed Central 2019-09-21 /pmc/articles/PMC6754629/ /pubmed/31540583 http://dx.doi.org/10.1186/s13256-019-2228-z Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Yamasaki, Arina
Bito, Daisuke
Eto, Erina
Matsumoto, Keiichiro
Nakamura, Megumi
Miyazaki, Junji
Matsumoto, Kenichi
Masuda, Masanori
Mori, Daisuke
Yoshimura, Toru
Focal segmental glomerulosclerosis in which urinary protein improved after surgical treatment for acromegaly: a case report
title Focal segmental glomerulosclerosis in which urinary protein improved after surgical treatment for acromegaly: a case report
title_full Focal segmental glomerulosclerosis in which urinary protein improved after surgical treatment for acromegaly: a case report
title_fullStr Focal segmental glomerulosclerosis in which urinary protein improved after surgical treatment for acromegaly: a case report
title_full_unstemmed Focal segmental glomerulosclerosis in which urinary protein improved after surgical treatment for acromegaly: a case report
title_short Focal segmental glomerulosclerosis in which urinary protein improved after surgical treatment for acromegaly: a case report
title_sort focal segmental glomerulosclerosis in which urinary protein improved after surgical treatment for acromegaly: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754629/
https://www.ncbi.nlm.nih.gov/pubmed/31540583
http://dx.doi.org/10.1186/s13256-019-2228-z
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