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Selective deployment of transcription factor paralogs with submaximal strength facilitates gene regulation in the immune system

In multicellular organisms, duplicated genes can diverge through tissue-specific gene expression patterns, as exemplified by highly regulated expression of Runx transcription factor paralogs with apparent functional redundancy. Here we asked what cell type-specific biologies might be supported by th...

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Detalles Bibliográficos
Autores principales: Bruno, Ludovica, Ramlall, Vijendra, Studer, Romain A., Sauer, Stephan, Bradley, David, Dharmalingam, Gopuraja, Carroll, Thomas, Ghoneim, Mohamed, Chopin, Michaël, Nutt, Stephen L., Elderkin, Sarah, Rueda, David S., Fisher, Amanda G., Siggers, Trevor, Beltrao, Pedro, Merkenschlager, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754753/
https://www.ncbi.nlm.nih.gov/pubmed/31451789
http://dx.doi.org/10.1038/s41590-019-0471-5

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