Mouse IgG2a Antibodies Specific for the Commensal Streptococcus mitis Show Stronger Cross-Reactivity with Streptococcus pneumoniae than IgG1 Antibodies

Here we show that mouse IgG2a and IgG1 antibodies specific for the commensal Streptococcus mitis cross-react with pathogen Streptococcus pneumoniae serotypes 2 and 4, although the cross-reactivity conferred by IgG2a is stronger than that by IgG1 antibodies. These findings may be important for unders...

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Autores principales: Shekhar, Sudhanshu, Khan, Rabia, Khan, Ata Ul Razzaq, Petersen, Fernanda Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754875/
https://www.ncbi.nlm.nih.gov/pubmed/31583259
http://dx.doi.org/10.1155/2019/7906724
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author Shekhar, Sudhanshu
Khan, Rabia
Khan, Ata Ul Razzaq
Petersen, Fernanda Cristina
author_facet Shekhar, Sudhanshu
Khan, Rabia
Khan, Ata Ul Razzaq
Petersen, Fernanda Cristina
author_sort Shekhar, Sudhanshu
collection PubMed
description Here we show that mouse IgG2a and IgG1 antibodies specific for the commensal Streptococcus mitis cross-react with pathogen Streptococcus pneumoniae serotypes 2 and 4, although the cross-reactivity conferred by IgG2a is stronger than that by IgG1 antibodies. These findings may be important for understanding the S. mitis-induced IgG isotype responses and have consequences for the development of an effective pneumococcal vaccine.
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spelling pubmed-67548752019-10-03 Mouse IgG2a Antibodies Specific for the Commensal Streptococcus mitis Show Stronger Cross-Reactivity with Streptococcus pneumoniae than IgG1 Antibodies Shekhar, Sudhanshu Khan, Rabia Khan, Ata Ul Razzaq Petersen, Fernanda Cristina J Immunol Res Research Article Here we show that mouse IgG2a and IgG1 antibodies specific for the commensal Streptococcus mitis cross-react with pathogen Streptococcus pneumoniae serotypes 2 and 4, although the cross-reactivity conferred by IgG2a is stronger than that by IgG1 antibodies. These findings may be important for understanding the S. mitis-induced IgG isotype responses and have consequences for the development of an effective pneumococcal vaccine. Hindawi 2019-09-10 /pmc/articles/PMC6754875/ /pubmed/31583259 http://dx.doi.org/10.1155/2019/7906724 Text en Copyright © 2019 Sudhanshu Shekhar et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Shekhar, Sudhanshu
Khan, Rabia
Khan, Ata Ul Razzaq
Petersen, Fernanda Cristina
Mouse IgG2a Antibodies Specific for the Commensal Streptococcus mitis Show Stronger Cross-Reactivity with Streptococcus pneumoniae than IgG1 Antibodies
title Mouse IgG2a Antibodies Specific for the Commensal Streptococcus mitis Show Stronger Cross-Reactivity with Streptococcus pneumoniae than IgG1 Antibodies
title_full Mouse IgG2a Antibodies Specific for the Commensal Streptococcus mitis Show Stronger Cross-Reactivity with Streptococcus pneumoniae than IgG1 Antibodies
title_fullStr Mouse IgG2a Antibodies Specific for the Commensal Streptococcus mitis Show Stronger Cross-Reactivity with Streptococcus pneumoniae than IgG1 Antibodies
title_full_unstemmed Mouse IgG2a Antibodies Specific for the Commensal Streptococcus mitis Show Stronger Cross-Reactivity with Streptococcus pneumoniae than IgG1 Antibodies
title_short Mouse IgG2a Antibodies Specific for the Commensal Streptococcus mitis Show Stronger Cross-Reactivity with Streptococcus pneumoniae than IgG1 Antibodies
title_sort mouse igg2a antibodies specific for the commensal streptococcus mitis show stronger cross-reactivity with streptococcus pneumoniae than igg1 antibodies
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754875/
https://www.ncbi.nlm.nih.gov/pubmed/31583259
http://dx.doi.org/10.1155/2019/7906724
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AT khanataulrazzaq mouseigg2aantibodiesspecificforthecommensalstreptococcusmitisshowstrongercrossreactivitywithstreptococcuspneumoniaethanigg1antibodies
AT petersenfernandacristina mouseigg2aantibodiesspecificforthecommensalstreptococcusmitisshowstrongercrossreactivitywithstreptococcuspneumoniaethanigg1antibodies

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