Acute Myeloid Leukemia in an Infant with t(8;19)(p11.2;q13) Translocation: Case Report and a Review of the Literature

Acute myeloid leukemia (AML) patients with t(8;16)(p11.2;p13) constitute a small subgroup with a distinct genetic and clinical profile. We present a unique case of a female infant with monocytic AML associated with t(8;19)(p11.2;q13.3), a rarely reported variation of t(8;16)(p11.2;p13). The patient...

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Autores principales: Eason, Ashley C., Bunting, Silvia T., Peterson, Jess F., Saxe, Debra, Sabnis, Himalee S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754882/
https://www.ncbi.nlm.nih.gov/pubmed/31583141
http://dx.doi.org/10.1155/2019/4198415
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author Eason, Ashley C.
Bunting, Silvia T.
Peterson, Jess F.
Saxe, Debra
Sabnis, Himalee S.
author_facet Eason, Ashley C.
Bunting, Silvia T.
Peterson, Jess F.
Saxe, Debra
Sabnis, Himalee S.
author_sort Eason, Ashley C.
collection PubMed
description Acute myeloid leukemia (AML) patients with t(8;16)(p11.2;p13) constitute a small subgroup with a distinct genetic and clinical profile. We present a unique case of a female infant with monocytic AML associated with t(8;19)(p11.2;q13.3), a rarely reported variation of t(8;16)(p11.2;p13). The patient presented with leukemia cutis and demonstrated erythrophagocytosis in the diagnostic bone marrow. She responded well to standard AML chemotherapy and is currently in remission. Here, we highlight her case as the youngest AML patient with t(8;19) described in the literature, discuss the significance and prognostic implications of this genetic variant, and review 8p11.2 fusion proteins in AML.
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spelling pubmed-67548822019-10-03 Acute Myeloid Leukemia in an Infant with t(8;19)(p11.2;q13) Translocation: Case Report and a Review of the Literature Eason, Ashley C. Bunting, Silvia T. Peterson, Jess F. Saxe, Debra Sabnis, Himalee S. Case Rep Hematol Case Report Acute myeloid leukemia (AML) patients with t(8;16)(p11.2;p13) constitute a small subgroup with a distinct genetic and clinical profile. We present a unique case of a female infant with monocytic AML associated with t(8;19)(p11.2;q13.3), a rarely reported variation of t(8;16)(p11.2;p13). The patient presented with leukemia cutis and demonstrated erythrophagocytosis in the diagnostic bone marrow. She responded well to standard AML chemotherapy and is currently in remission. Here, we highlight her case as the youngest AML patient with t(8;19) described in the literature, discuss the significance and prognostic implications of this genetic variant, and review 8p11.2 fusion proteins in AML. Hindawi 2019-09-08 /pmc/articles/PMC6754882/ /pubmed/31583141 http://dx.doi.org/10.1155/2019/4198415 Text en Copyright © 2019 Ashley C. Eason et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Eason, Ashley C.
Bunting, Silvia T.
Peterson, Jess F.
Saxe, Debra
Sabnis, Himalee S.
Acute Myeloid Leukemia in an Infant with t(8;19)(p11.2;q13) Translocation: Case Report and a Review of the Literature
title Acute Myeloid Leukemia in an Infant with t(8;19)(p11.2;q13) Translocation: Case Report and a Review of the Literature
title_full Acute Myeloid Leukemia in an Infant with t(8;19)(p11.2;q13) Translocation: Case Report and a Review of the Literature
title_fullStr Acute Myeloid Leukemia in an Infant with t(8;19)(p11.2;q13) Translocation: Case Report and a Review of the Literature
title_full_unstemmed Acute Myeloid Leukemia in an Infant with t(8;19)(p11.2;q13) Translocation: Case Report and a Review of the Literature
title_short Acute Myeloid Leukemia in an Infant with t(8;19)(p11.2;q13) Translocation: Case Report and a Review of the Literature
title_sort acute myeloid leukemia in an infant with t(8;19)(p11.2;q13) translocation: case report and a review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754882/
https://www.ncbi.nlm.nih.gov/pubmed/31583141
http://dx.doi.org/10.1155/2019/4198415
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