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Chronic Gestational Inflammation: Transfer of Maternal Adaptation over Two Generations of Progeny
Changes in the in utero environment result in generational transfer of maladapted physiology in the context of conditions such as stress, obesity, and anxiety. Given the significant contribution of noncommunicable diseases—which are characterised by chronic inflammation—to population mortality, the...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754931/ https://www.ncbi.nlm.nih.gov/pubmed/31582905 http://dx.doi.org/10.1155/2019/9160941 |
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author | Adams, R. C. M. Smith, C. |
author_facet | Adams, R. C. M. Smith, C. |
author_sort | Adams, R. C. M. |
collection | PubMed |
description | Changes in the in utero environment result in generational transfer of maladapted physiology in the context of conditions such as stress, obesity, and anxiety. Given the significant contribution of noncommunicable diseases—which are characterised by chronic inflammation—to population mortality, the potential for chronic maternal inflammation mediating foetal programming is a growing concern. The extent of generational transfer in terms of immune functionality and leukocyte glucocorticoid sensitivity was investigated over two generations of offspring (F1 and F2) in a model of chronic LPS-induced maternal inflammation in C57/BL/6 mice. Maternal inflammation resulted in glucocorticoid hypersensitivity (increased glucocorticoid receptor expression levels) in the majority of leukocyte subpopulations in both F1 and F2 offspring. Furthermore, splenocytes stimulated with LPS in vitro exhibited exacerbated inflammatory cytokine responses, which were even more prominent in F2 than F1; this effect could be ascribed to NLRP3 inflammasome hyperactivity in F1 but not F2. Current data illustrates that parental chronic inflammation may mediate the inflammatory profile in offspring, potentially propagating a maladapted proinflammatory phenotype in subsequent generations. |
format | Online Article Text |
id | pubmed-6754931 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-67549312019-10-03 Chronic Gestational Inflammation: Transfer of Maternal Adaptation over Two Generations of Progeny Adams, R. C. M. Smith, C. Mediators Inflamm Research Article Changes in the in utero environment result in generational transfer of maladapted physiology in the context of conditions such as stress, obesity, and anxiety. Given the significant contribution of noncommunicable diseases—which are characterised by chronic inflammation—to population mortality, the potential for chronic maternal inflammation mediating foetal programming is a growing concern. The extent of generational transfer in terms of immune functionality and leukocyte glucocorticoid sensitivity was investigated over two generations of offspring (F1 and F2) in a model of chronic LPS-induced maternal inflammation in C57/BL/6 mice. Maternal inflammation resulted in glucocorticoid hypersensitivity (increased glucocorticoid receptor expression levels) in the majority of leukocyte subpopulations in both F1 and F2 offspring. Furthermore, splenocytes stimulated with LPS in vitro exhibited exacerbated inflammatory cytokine responses, which were even more prominent in F2 than F1; this effect could be ascribed to NLRP3 inflammasome hyperactivity in F1 but not F2. Current data illustrates that parental chronic inflammation may mediate the inflammatory profile in offspring, potentially propagating a maladapted proinflammatory phenotype in subsequent generations. Hindawi 2019-08-25 /pmc/articles/PMC6754931/ /pubmed/31582905 http://dx.doi.org/10.1155/2019/9160941 Text en Copyright © 2019 R. C. M. Adams and C. Smith. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Adams, R. C. M. Smith, C. Chronic Gestational Inflammation: Transfer of Maternal Adaptation over Two Generations of Progeny |
title | Chronic Gestational Inflammation: Transfer of Maternal Adaptation over Two Generations of Progeny |
title_full | Chronic Gestational Inflammation: Transfer of Maternal Adaptation over Two Generations of Progeny |
title_fullStr | Chronic Gestational Inflammation: Transfer of Maternal Adaptation over Two Generations of Progeny |
title_full_unstemmed | Chronic Gestational Inflammation: Transfer of Maternal Adaptation over Two Generations of Progeny |
title_short | Chronic Gestational Inflammation: Transfer of Maternal Adaptation over Two Generations of Progeny |
title_sort | chronic gestational inflammation: transfer of maternal adaptation over two generations of progeny |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754931/ https://www.ncbi.nlm.nih.gov/pubmed/31582905 http://dx.doi.org/10.1155/2019/9160941 |
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