Effects of Lycium barbarum Polysaccharides on Health and Aging of C. elegans Depend on daf-12/daf-16

As the global population ages, searching for drugs and functional foods which can slow down the aging process has attracted a number of researchers. In this paper, the Lycium barbarum polysaccharides (LBP) extracted from Lycium barbarum was characterized and the effects of LBP on the aging and healt...

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Autores principales: Zhang, Zhaokang, Zhou, Yannan, Fan, Haitao, Billy, Kirunda John, Zhao, Yunjie, Zhan, Xuan, Yang, Lijian, Jia, Ya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754959/
https://www.ncbi.nlm.nih.gov/pubmed/31583041
http://dx.doi.org/10.1155/2019/6379493
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author Zhang, Zhaokang
Zhou, Yannan
Fan, Haitao
Billy, Kirunda John
Zhao, Yunjie
Zhan, Xuan
Yang, Lijian
Jia, Ya
author_facet Zhang, Zhaokang
Zhou, Yannan
Fan, Haitao
Billy, Kirunda John
Zhao, Yunjie
Zhan, Xuan
Yang, Lijian
Jia, Ya
author_sort Zhang, Zhaokang
collection PubMed
description As the global population ages, searching for drugs and functional foods which can slow down the aging process has attracted a number of researchers. In this paper, the Lycium barbarum polysaccharides (LBP) extracted from Lycium barbarum was characterized and the effects of LBP on the aging and health of C. elegans were studied. Results showed that LBP can prolong the lifespan, improve the abilities to withstand environmental stress, enhance reproductive potentials, and maintain muscle integrity of C. elegans. By using genetically mutated C. elegans strains, RNAi gene silencing, and measuring the mRNA expression level, it was demonstrated that the lifespan of C. elegans was extended by LBP mainly through sir-2.1, daf-12, and daf-16. The present study might provide a basis for further study of LBP as a food or drug to interfere with aging and reduce the incidence of age-related diseases.
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spelling pubmed-67549592019-10-03 Effects of Lycium barbarum Polysaccharides on Health and Aging of C. elegans Depend on daf-12/daf-16 Zhang, Zhaokang Zhou, Yannan Fan, Haitao Billy, Kirunda John Zhao, Yunjie Zhan, Xuan Yang, Lijian Jia, Ya Oxid Med Cell Longev Research Article As the global population ages, searching for drugs and functional foods which can slow down the aging process has attracted a number of researchers. In this paper, the Lycium barbarum polysaccharides (LBP) extracted from Lycium barbarum was characterized and the effects of LBP on the aging and health of C. elegans were studied. Results showed that LBP can prolong the lifespan, improve the abilities to withstand environmental stress, enhance reproductive potentials, and maintain muscle integrity of C. elegans. By using genetically mutated C. elegans strains, RNAi gene silencing, and measuring the mRNA expression level, it was demonstrated that the lifespan of C. elegans was extended by LBP mainly through sir-2.1, daf-12, and daf-16. The present study might provide a basis for further study of LBP as a food or drug to interfere with aging and reduce the incidence of age-related diseases. Hindawi 2019-09-10 /pmc/articles/PMC6754959/ /pubmed/31583041 http://dx.doi.org/10.1155/2019/6379493 Text en Copyright © 2019 Zhaokang Zhang et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhang, Zhaokang
Zhou, Yannan
Fan, Haitao
Billy, Kirunda John
Zhao, Yunjie
Zhan, Xuan
Yang, Lijian
Jia, Ya
Effects of Lycium barbarum Polysaccharides on Health and Aging of C. elegans Depend on daf-12/daf-16
title Effects of Lycium barbarum Polysaccharides on Health and Aging of C. elegans Depend on daf-12/daf-16
title_full Effects of Lycium barbarum Polysaccharides on Health and Aging of C. elegans Depend on daf-12/daf-16
title_fullStr Effects of Lycium barbarum Polysaccharides on Health and Aging of C. elegans Depend on daf-12/daf-16
title_full_unstemmed Effects of Lycium barbarum Polysaccharides on Health and Aging of C. elegans Depend on daf-12/daf-16
title_short Effects of Lycium barbarum Polysaccharides on Health and Aging of C. elegans Depend on daf-12/daf-16
title_sort effects of lycium barbarum polysaccharides on health and aging of c. elegans depend on daf-12/daf-16
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754959/
https://www.ncbi.nlm.nih.gov/pubmed/31583041
http://dx.doi.org/10.1155/2019/6379493
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