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Cell wall inhibition in L-forms or via β-lactam antibiotics induces reactive oxygen-mediated bacterial killing through increased glycolytic flux
The peptidoglycan (PG) cell wall is an essential structure for the growth of most bacteria. However, many are capable of switching into a wall-deficient L-form state, which is resistant to antibiotics that target cell wall synthesis, under osmoprotective conditions, including host environments. L-fo...
Autores principales: | Kawai, Yoshikazu, Mercier, Romain, Mickiewicz, Katarzyna, Serafini, Agnese, de Carvalho, Luiz Pedro Sório, Errington, Jeff |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755032/ https://www.ncbi.nlm.nih.gov/pubmed/31285586 http://dx.doi.org/10.1038/s41564-019-0497-3 |
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