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Cyclic oligoadenylate signalling mediates Mycobacterium tuberculosis CRISPR defence

The CRISPR system provides adaptive immunity against mobile genetic elements (MGE) in prokaryotes. In type III CRISPR systems, an effector complex programmed by CRISPR RNA detects invading RNA, triggering a multi-layered defence that includes target RNA cleavage, licencing of an HD DNA nuclease doma...

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Detalles Bibliográficos
Autores principales:	Grüschow, Sabine, Athukoralage, Januka S, Graham, Shirley, Hoogeboom, Tess, White, Malcolm F
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755085/ https://www.ncbi.nlm.nih.gov/pubmed/31392987 http://dx.doi.org/10.1093/nar/gkz676

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