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The MLL1 trimeric catalytic complex is a dynamic conformational ensemble stabilized by multiple weak interactions

Histone H3K4 methylation is an epigenetic mark associated with actively transcribed genes. This modification is catalyzed by the mixed lineage leukaemia (MLL) family of histone methyltransferases including MLL1, MLL2, MLL3, MLL4, SET1A and SET1B. The catalytic activity of this family is dependent on...

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Detalles Bibliográficos
Autores principales:	Kaustov, Lilia, Lemak, Alexander, Wu, Hong, Faini, Marco, Fan, Lixin, Fang, Xianyang, Zeng, Hong, Duan, Shili, Allali-Hassani, Abdellah, Li, Fengling, Wei, Yong, Vedadi, Masoud, Aebersold, Ruedi, Wang, Yunxing, Houliston, Scott, Arrowsmith, Cheryl H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755125/ https://www.ncbi.nlm.nih.gov/pubmed/31400120 http://dx.doi.org/10.1093/nar/gkz697

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