Cargando…

Effect of chondrocyte mitochondrial dysfunction on cartilage degeneration: A possible pathway for osteoarthritis pathology at the subcellular level

Previous studies identified that chondrocyte apoptosis serves an important role in osteoarthritis (OA). However, the mechanisms of cartilage degeneration induced by apoptosis remain unclear. The present study investigated the role of mitochondrial dysfunction in OA pathology. A total of 30 cartilage...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Heng, Li, Zhuoyang, Cao, Yongping, Cui, Yunpeng, Yang, Xin, Meng, Zhichao, Wang, Rui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2019
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755144/ https://www.ncbi.nlm.nih.gov/pubmed/31432161 http://dx.doi.org/10.3892/mmr.2019.10559

Ejemplares similares

Efficacy of magnetic resonance imaging with an SPGR sequence for the early evaluation of knee cartilage degeneration and the relationship between cartilage and other tissues
por: Yang, Xin, et al.
Publicado: (2019)

Isorhynchophylline alleviates cartilage degeneration in osteoarthritis by activating autophagy of chondrocytes
por: Jiang, Jieyun, et al.
Publicado: (2023)

Statin prevents chondrocyte aging and degeneration of articular cartilage in osteoarthritis (OA)
por: Yudoh, Kazuo, et al.
Publicado: (2010)

Pink1-Mediated Chondrocytic Mitophagy Contributes to Cartilage Degeneration in Osteoarthritis
por: Shin, Hyo Jung, et al.
Publicado: (2019)

Calcium chelator BAPTA-AM protects against iron overload-induced chondrocyte mitochondrial dysfunction and cartilage degeneration
por: Jing, Xingzhi, et al.
Publicado: (2021)

Flightless I is a catabolic factor of chondrocytes that promotes hypertrophy and cartilage degeneration in osteoarthritis
por: Ebata, Taku, et al.
Publicado: (2021)

ENZYME ACTIVITIES IN CHICK EMBRYONIC CARTILAGE : Their Subcellular Distribution in Isolated Chondrocytes
por: Arsenis, C., et al.
Publicado: (1971)

Role of Chondrocytes in Cartilage Formation, Progression of Osteoarthritis and Cartilage Regeneration
por: Akkiraju, Hemanth, et al.
Publicado: (2015)

Mitochondrial transfer from bone-marrow-derived mesenchymal stromal cells to chondrocytes protects against cartilage degenerative mitochondrial dysfunction in rats chondrocytes
por: Wang, Rui, et al.
Publicado: (2021)

Calcitonin attenuates cartilage degeneration and nociception in an experimental rat model of osteoarthritis: role of TGF-β in chondrocytes
por: Wen, Zhi-Hong, et al.
Publicado: (2016)

The endoplasmic reticulum stress induced by tunicamycin affects the viability and autophagy activity of chondrocytes
por: Wu, Hao, et al.
Publicado: (2020)

Mechanical overloading causes mitochondrial superoxide and SOD2 imbalance in chondrocytes resulting in cartilage degeneration
por: Koike, Masato, et al.
Publicado: (2015)

miR-152 Attenuates Apoptosis in Chondrocytes and Degeneration of Cartilages in Osteoarthritis Rats via TCF-4 Pathway
por: Wan, Daqian, et al.
Publicado: (2020)

Low‐intensity pulsed ultrasound inhibits VEGFA expression in chondrocytes and protects against cartilage degeneration in experimental osteoarthritis
por: Guan, Mengtong, et al.
Publicado: (2020)

Urolithin A improves mitochondrial health, reduces cartilage degeneration, and alleviates pain in osteoarthritis
por: D'Amico, Davide, et al.
Publicado: (2022)

The Role of Chondrocyte Morphology and Volume in Controlling Phenotype—Implications for Osteoarthritis, Cartilage Repair, and Cartilage Engineering
por: Hall, Andrew C.
Publicado: (2019)

Oxidative stress induces chondrocyte telomere instability and chondrocyte dysfunctions in osteoarthritis
por: Yudoh, K, et al.
Publicado: (2003)

Chondrocyte-derived exosomes promote cartilage calcification in temporomandibular joint osteoarthritis
por: Liu, Qian, et al.
Publicado: (2022)

p66shc siRNA Nanoparticles Ameliorate Chondrocytic Mitochondrial Dysfunction in Osteoarthritis
por: Shin, Hyo Jung, et al.
Publicado: (2020)

Sanmiao formula inhibits chondrocyte apoptosis and cartilage matrix degradation in a rat model of osteoarthritis
por: XU, YING, et al.
Publicado: (2014)

Decreased histone deacetylase 4 is associated with human osteoarthritis cartilage degeneration by releasing histone deacetylase 4 inhibition of runt-related transcription factor-2 and increasing osteoarthritis-related genes: a novel mechanism of human osteoarthritis cartilage degeneration
por: Cao, Kun, et al.
Publicado: (2014)

Berberine ameliorates cartilage degeneration in interleukin-1β-stimulated rat chondrocytes and in a rat model of osteoarthritis via Akt signalling
por: Zhao, Honghai, et al.
Publicado: (2014)

The Level of Histone Deacetylase 4 is Associated with Aging Cartilage Degeneration and Chondrocyte Hypertrophy
por: Dong, Zhengquan, et al.
Publicado: (2022)

Iron triggers the early stages of cartilage degeneration in vitro: The role of articular chondrocytes
por: Ferreira, A.V., et al.
Publicado: (2021)

Cartilage Degeneration and Alignment in Severe Varus Knee Osteoarthritis
por: Nakagawa, Yasuaki, et al.
Publicado: (2015)

High TRB3 expression induces chondrocyte autophagy and senescence in osteoarthritis cartilage
por: Gu, Yanqing, et al.
Publicado: (2022)

Viability of Pathologic Cartilage Fragments as a Source for Autologous Chondrocyte Cultures
por: Guillén-García, Pedro, et al.
Publicado: (2015)

Selective STAT3 Inhibitor Alantolactone Ameliorates Osteoarthritis via Regulating Chondrocyte Autophagy and Cartilage Homeostasis
por: Pei, Wenbin, et al.
Publicado: (2021)

Trimanganese Tetroxide Nanozyme protects Cartilage against Degeneration by Reducing Oxidative Stress in Osteoarthritis
por: Wang, Wenhan, et al.
Publicado: (2023)

Irisin Mitigates Oxidative Stress, Chondrocyte Dysfunction and Osteoarthritis Development through Regulating Mitochondrial Integrity and Autophagy
por: Wang, Feng-Sheng, et al.
Publicado: (2020)

Advanced oxidation protein products increase TNF-α and IL-1β expression in chondrocytes via NADPH oxidase 4 and accelerate cartilage degeneration in osteoarthritis progression
por: Liao, Cong-Rui, et al.
Publicado: (2019)

Intraarticular Ligament Degeneration Is Interrelated with Cartilage and Bone Destruction in Osteoarthritis
por: Schulze-Tanzil, Gundula
Publicado: (2019)

New insights into the interplay between autophagy and cartilage degeneration in osteoarthritis
por: Lv, Xiaoman, et al.
Publicado: (2022)

Role of Syndecan-4 in the Inhibition of Articular Cartilage Degeneration in Osteoarthritis
por: Hattori, Yoshio, et al.
Publicado: (2023)

The Age-Related Changes in Cartilage and Osteoarthritis
por: Li, YongPing, et al.
Publicado: (2013)

Repair of cartilage defects in osteoarthritis rats with induced pluripotent stem cell derived chondrocytes
por: Zhu, Yanxia, et al.
Publicado: (2016)

XMU-MP-1 attenuates osteoarthritis via inhibiting cartilage degradation and chondrocyte apoptosis
por: Hao, Xue, et al.
Publicado: (2022)

Cartilage repair and inhibition of the progression of cartilage degeneration after transplantation of allogeneic chondrocyte sheets in a nontraumatic early arthritis model
por: Takatori, Naoki, et al.
Publicado: (2018)

Tissue engineering: chondrocytes and cartilage
por: Hardingham, Tim, et al.
Publicado: (2002)

TUG1 knockdown promoted viability and inhibited apoptosis and cartilage ECM degradation in chondrocytes via the miR-17-5p/FUT1 pathway in osteoarthritis
por: Li, Zhichao, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_1pn7qdj01gten2bu08padfe98l