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COL12A1, a novel potential prognostic factor and therapeutic target in gastric cancer

Dysregulation of collagen type XII α1 chain (COL12A1) has been found in several cancer types and could be involved in tumor progression. However, its clinical significance in gastric cancer (GC) remains under exploration. Online databases (Gene Expression Omnibus and UALCAN), reverse transcription-q...

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Autores principales: Jiang, Xiaoxia, Wu, Mengjie, Xu, Xin, Zhang, Liwei, Huang, Yingying, Xu, Zhenzhen, He, Kuifeng, Wang, Haiyong, Wang, Haohao, Teng, Lisong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755194/
https://www.ncbi.nlm.nih.gov/pubmed/31432110
http://dx.doi.org/10.3892/mmr.2019.10548
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author Jiang, Xiaoxia
Wu, Mengjie
Xu, Xin
Zhang, Liwei
Huang, Yingying
Xu, Zhenzhen
He, Kuifeng
Wang, Haiyong
Wang, Haohao
Teng, Lisong
author_facet Jiang, Xiaoxia
Wu, Mengjie
Xu, Xin
Zhang, Liwei
Huang, Yingying
Xu, Zhenzhen
He, Kuifeng
Wang, Haiyong
Wang, Haohao
Teng, Lisong
author_sort Jiang, Xiaoxia
collection PubMed
description Dysregulation of collagen type XII α1 chain (COL12A1) has been found in several cancer types and could be involved in tumor progression. However, its clinical significance in gastric cancer (GC) remains under exploration. Online databases (Gene Expression Omnibus and UALCAN), reverse transcription-quantitative PCR and immunohistochemistry were utilized in the present study to evaluate the expression of COL12A1 in GC tissues and cell lines. It was found that COL12A1 expression was notably upregulated in GC. Clinicopathological analysis showed that elevated COL12A1 expression was positively correlated with tumor invasiveness, metastasis and advanced clinical stage. The prognostic analysis suggested that high COL12A1 expression contributed to poor overall survival. Multivariate Cox analysis indicated that COL12A1 overexpression was a powerful independent prognostic indicator in patients with GC (hazard ratio, 1.896; 95% CI, 1.267–2.837; P=0.002). The results highlighted the importance of COL12A1 in GC and suggested its potential role as a candidate for clinical outcome prediction and targeted therapy in patients with GC.
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spelling pubmed-67551942019-09-25 COL12A1, a novel potential prognostic factor and therapeutic target in gastric cancer Jiang, Xiaoxia Wu, Mengjie Xu, Xin Zhang, Liwei Huang, Yingying Xu, Zhenzhen He, Kuifeng Wang, Haiyong Wang, Haohao Teng, Lisong Mol Med Rep Articles Dysregulation of collagen type XII α1 chain (COL12A1) has been found in several cancer types and could be involved in tumor progression. However, its clinical significance in gastric cancer (GC) remains under exploration. Online databases (Gene Expression Omnibus and UALCAN), reverse transcription-quantitative PCR and immunohistochemistry were utilized in the present study to evaluate the expression of COL12A1 in GC tissues and cell lines. It was found that COL12A1 expression was notably upregulated in GC. Clinicopathological analysis showed that elevated COL12A1 expression was positively correlated with tumor invasiveness, metastasis and advanced clinical stage. The prognostic analysis suggested that high COL12A1 expression contributed to poor overall survival. Multivariate Cox analysis indicated that COL12A1 overexpression was a powerful independent prognostic indicator in patients with GC (hazard ratio, 1.896; 95% CI, 1.267–2.837; P=0.002). The results highlighted the importance of COL12A1 in GC and suggested its potential role as a candidate for clinical outcome prediction and targeted therapy in patients with GC. D.A. Spandidos 2019-10 2019-08-01 /pmc/articles/PMC6755194/ /pubmed/31432110 http://dx.doi.org/10.3892/mmr.2019.10548 Text en Copyright: © Jiang et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Jiang, Xiaoxia
Wu, Mengjie
Xu, Xin
Zhang, Liwei
Huang, Yingying
Xu, Zhenzhen
He, Kuifeng
Wang, Haiyong
Wang, Haohao
Teng, Lisong
COL12A1, a novel potential prognostic factor and therapeutic target in gastric cancer
title COL12A1, a novel potential prognostic factor and therapeutic target in gastric cancer
title_full COL12A1, a novel potential prognostic factor and therapeutic target in gastric cancer
title_fullStr COL12A1, a novel potential prognostic factor and therapeutic target in gastric cancer
title_full_unstemmed COL12A1, a novel potential prognostic factor and therapeutic target in gastric cancer
title_short COL12A1, a novel potential prognostic factor and therapeutic target in gastric cancer
title_sort col12a1, a novel potential prognostic factor and therapeutic target in gastric cancer
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755194/
https://www.ncbi.nlm.nih.gov/pubmed/31432110
http://dx.doi.org/10.3892/mmr.2019.10548
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