Super‐Resolution Microscopy: Hypotonic Stress Induces Fast, Reversible Degradation of the Vimentin Cytoskeleton via Intracellular Calcium Release (Adv. Sci. 18/2019)

In article number 1900865, Ke Xu and co‐workers report, through super‐resolution microscopy, an unexpected, fast degradation pathway of the vimentin cytoskeletal system under hypo‐osmotic stress. Together with calcium imaging and biochemical analysis, the study further unveils that this degradation...

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Detalles Bibliográficos
Autores principales: Pan, Leiting, Zhang, Ping, Hu, Fen, Yan, Rui, He, Manni, Li, Wan, Xu, Jingjun, Xu, Ke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755515/
http://dx.doi.org/10.1002/advs.201970112
Descripción
Sumario:In article number 1900865, Ke Xu and co‐workers report, through super‐resolution microscopy, an unexpected, fast degradation pathway of the vimentin cytoskeletal system under hypo‐osmotic stress. Together with calcium imaging and biochemical analysis, the study further unveils that this degradation is due to proteolysis by the calcium‐dependent protease calpain, activated by hypotonic stress‐induced calcium release from intracellular stores. [Image: see text]

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