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Total synthesis of griseusins and elucidation of the griseusin mechanism of action

A divergent modular strategy for the enantioselective total synthesis of 12 naturally-occurring griseusin type pyranonaphthoquinones and 8 structurally-similar analogues is described. Key synthetic highlights include Cu-catalyzed enantioselective boration–hydroxylation and hydroxyl-directed C–H olef...

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Detalles Bibliográficos
Autores principales:	Zhang, Yinan, Ye, Qing, Ponomareva, Larissa V., Cao, Yanan, Liu, Yang, Cui, Zheng, Van Lanen, Steven G., Voss, S. Randal, She, Qing-Bai, Thorson, Jon S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2019
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755659/ https://www.ncbi.nlm.nih.gov/pubmed/31583069 http://dx.doi.org/10.1039/c9sc02289a

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