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Prescription pattern & adverse drug reactions of prokinetics

BACKGROUND & OBJECTIVES: Prokinetics are extensively prescribed leading to several adverse events (AEs). The aim of this study was to assess the prescription pattern in patients receiving prokinetics, and characteristics of adverse drug reactions (ADRs) in an outpatient department set up in a te...

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Autores principales: Biswas, Mansij, Singh, Kritarth Naman Mithileshwar, Shetty, Yashashri C., Koli, Paresh G., Ingawale, Sushrut, Bhatia, Shobna J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755782/
https://www.ncbi.nlm.nih.gov/pubmed/31496527
http://dx.doi.org/10.4103/ijmr.IJMR_1039_17
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author Biswas, Mansij
Singh, Kritarth Naman Mithileshwar
Shetty, Yashashri C.
Koli, Paresh G.
Ingawale, Sushrut
Bhatia, Shobna J.
author_facet Biswas, Mansij
Singh, Kritarth Naman Mithileshwar
Shetty, Yashashri C.
Koli, Paresh G.
Ingawale, Sushrut
Bhatia, Shobna J.
author_sort Biswas, Mansij
collection PubMed
description BACKGROUND & OBJECTIVES: Prokinetics are extensively prescribed leading to several adverse events (AEs). The aim of this study was to assess the prescription pattern in patients receiving prokinetics, and characteristics of adverse drug reactions (ADRs) in an outpatient department set up in a tertiary care hospital in western India. METHODS: Patients attending outpatient departments of a tertiary care hospital and who had received prokinetic agent for at least seven days over the last one month were enrolled. Causality assessment of AEs was done and assessed for severity, preventability, seriousness and predictability. RESULTS: A total of 304 patients [161 males (52.96%); 143 females (47.04%)] were enrolled. Most prescriptions (299/304, 98%) included domperidone, most commonly prescribed as fixed-dose combination (FDC) with pantoprazole (274/304, 90%). Prokinetic dose was not mentioned in 251/304 (83%) prescriptions, and 18/304 (6%) did not mention frequency. Of the 378 AEs reported from 179 patients (47.35%), 306 (81%) were mild, all non-serious; 272 (72%) not preventable and 291 (77%) predictable in nature. Decreased appetite (n=31, 8.2%) and fatigue (n=27,7.14%) were most commonly reported. Causality assessment by the World Health Organization-Uppsala Monitoring Centre scale showed that 180 AEs were related to suspected drug (17 probable and 163 possible ADRs). Significant correlation was observed for AEs with increasing number of drugs per prescription (Spearman's R=+0.8, P=0.05) and with increasing therapy duration (Spearman's R=+1.00, P<0.001). INTERPRETATION & CONCLUSIONS: Our findings showed that prokinetics were often prescribed as FDCs, with incomplete prescriptions. Domperidone was found to be associated with multiple AEs. It is suggested that regular prescription monitoring should be done in hospitals to encourage rational use of drugs.
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spelling pubmed-67557822019-09-30 Prescription pattern & adverse drug reactions of prokinetics Biswas, Mansij Singh, Kritarth Naman Mithileshwar Shetty, Yashashri C. Koli, Paresh G. Ingawale, Sushrut Bhatia, Shobna J. Indian J Med Res Original Article BACKGROUND & OBJECTIVES: Prokinetics are extensively prescribed leading to several adverse events (AEs). The aim of this study was to assess the prescription pattern in patients receiving prokinetics, and characteristics of adverse drug reactions (ADRs) in an outpatient department set up in a tertiary care hospital in western India. METHODS: Patients attending outpatient departments of a tertiary care hospital and who had received prokinetic agent for at least seven days over the last one month were enrolled. Causality assessment of AEs was done and assessed for severity, preventability, seriousness and predictability. RESULTS: A total of 304 patients [161 males (52.96%); 143 females (47.04%)] were enrolled. Most prescriptions (299/304, 98%) included domperidone, most commonly prescribed as fixed-dose combination (FDC) with pantoprazole (274/304, 90%). Prokinetic dose was not mentioned in 251/304 (83%) prescriptions, and 18/304 (6%) did not mention frequency. Of the 378 AEs reported from 179 patients (47.35%), 306 (81%) were mild, all non-serious; 272 (72%) not preventable and 291 (77%) predictable in nature. Decreased appetite (n=31, 8.2%) and fatigue (n=27,7.14%) were most commonly reported. Causality assessment by the World Health Organization-Uppsala Monitoring Centre scale showed that 180 AEs were related to suspected drug (17 probable and 163 possible ADRs). Significant correlation was observed for AEs with increasing number of drugs per prescription (Spearman's R=+0.8, P=0.05) and with increasing therapy duration (Spearman's R=+1.00, P<0.001). INTERPRETATION & CONCLUSIONS: Our findings showed that prokinetics were often prescribed as FDCs, with incomplete prescriptions. Domperidone was found to be associated with multiple AEs. It is suggested that regular prescription monitoring should be done in hospitals to encourage rational use of drugs. Wolters Kluwer - Medknow 2019-06 /pmc/articles/PMC6755782/ /pubmed/31496527 http://dx.doi.org/10.4103/ijmr.IJMR_1039_17 Text en Copyright: © 2019 Indian Journal of Medical Research http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Biswas, Mansij
Singh, Kritarth Naman Mithileshwar
Shetty, Yashashri C.
Koli, Paresh G.
Ingawale, Sushrut
Bhatia, Shobna J.
Prescription pattern & adverse drug reactions of prokinetics
title Prescription pattern & adverse drug reactions of prokinetics
title_full Prescription pattern & adverse drug reactions of prokinetics
title_fullStr Prescription pattern & adverse drug reactions of prokinetics
title_full_unstemmed Prescription pattern & adverse drug reactions of prokinetics
title_short Prescription pattern & adverse drug reactions of prokinetics
title_sort prescription pattern & adverse drug reactions of prokinetics
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755782/
https://www.ncbi.nlm.nih.gov/pubmed/31496527
http://dx.doi.org/10.4103/ijmr.IJMR_1039_17
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