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A strategy for the selection of monovalent antibodies that span protein dimer interfaces

Ligand-induced dimerization is the predominant mechanism through which secreted proteins activate cell surface receptors to transmit essential biological signals. Cytokines are a large class of soluble proteins that dimerize transmembrane receptors into precise signaling topologies, but there is a n...

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Detalles Bibliográficos
Autores principales:	Spangler, Jamie B., Moraga, Ignacio, Jude, Kevin M., Savvides, Christina S., Garcia, K. Christopher
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2019
Materias:	Editors' Picks
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755802/ https://www.ncbi.nlm.nih.gov/pubmed/31387945 http://dx.doi.org/10.1074/jbc.RA119.009213

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