Distinct Fcα receptor N-glycans modulate the binding affinity to immunoglobulin A (IgA) antibodies

Human immunoglobulin A (IgA) is the most prevalent antibody class at mucosal sites with an important role in mucosal defense. Little is known about the impact of N-glycan modifications of IgA1 and IgA2 on binding to the Fcα receptor (FcαRI), which is also heavily glycosylated at its extracellular do...

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Detalles Bibliográficos
Autores principales: Göritzer, Kathrin, Turupcu, Aysegül, Maresch, Daniel, Novak, Jan, Altmann, Friedrich, Oostenbrink, Chris, Obinger, Christian, Strasser, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2019
Materias:
Glycobiology and Extracellular Matrices
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755811/
https://www.ncbi.nlm.nih.gov/pubmed/31362986
http://dx.doi.org/10.1074/jbc.RA119.009954

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755811/
https://www.ncbi.nlm.nih.gov/pubmed/31362986
http://dx.doi.org/10.1074/jbc.RA119.009954

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