Androgen receptor-modulatory microRNAs provide insight into therapy resistance and therapeutic targets in advanced prostate cancer

Androgen receptor (AR) signalling is a key prostate cancer (PC) driver, even in advanced ‘castrate-resistant’ disease (CRPC). To systematically identify microRNAs (miRs) modulating AR activity in lethal disease, hormone-responsive and -resistant PC cells expressing a luciferase-based AR reporter wer...

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Detalles Bibliográficos
Autores principales: Fletcher, Claire E., Sulpice, Eric, Combe, Stephanie, Shibakawa, Akifumi, Leach, Damien A., Hamilton, Mark P., Chrysostomou, Stelios L., Sharp, Adam, Welti, Jon, Yuan, Wei, Dart, Dafydd. A., Knight, Eleanor, Ning, Jian, Francis, Jeffrey C., Kounatidou, Evangelia E., Gaughan, Luke, Swain, Amanda, Lupold, Shawn E., de Bono, Johann S., McGuire, Sean E., Gidrol, Xavier, Bevan, Charlotte L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755970/
https://www.ncbi.nlm.nih.gov/pubmed/31043708
http://dx.doi.org/10.1038/s41388-019-0823-5

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