Cargando…

mTOR kinase leads to PTEN-loss-induced cellular senescence by phosphorylating p53

Loss of PTEN, the major negative regulator of the PI3K/AKT pathway induces a cellular senescence as a failsafe mechanism to defend against tumorigenesis, which is called PTEN-loss-induced cellular senescence (PICS). Although many studies have indicated that the mTOR pathway plays a critical role in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jung, Seung Hee, Hwang, Hyun Jung, Kang, Donghee, Park, Hyun A., Lee, Hyung Chul, Jeong, Daecheol, Lee, Keunwook, Park, Heon Joo, Ko, Young-Gyu, Lee, Jae-Seon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755978/ https://www.ncbi.nlm.nih.gov/pubmed/30337688 http://dx.doi.org/10.1038/s41388-018-0521-8

Ejemplares similares

Rapamycin-resistant and torin-sensitive mTOR signaling promotes the survival and proliferation of leukemic cells
por: Park, Seohyun, et al.
Publicado: (2016)

Temporal changes in mammalian target of rapamycin (mTOR) and phosphorylated-mTOR expressions in the hippocampal CA1 region of rat with vascular dementia
por: Park, Jin-A, et al.
Publicado: (2017)

Role of mTOR in the Development of Asthma in Mice With Cigarette Smoke-Induced Cellular Senescence
por: Lee, Hyun Seung, et al.
Publicado: (2021)

mTOR favors senescence over quiescence in p53-arrested cells
por: Schug, Thaddeus T.
Publicado: (2010)

Caveolin‐1 deficiency induces premature senescence with mitochondrial dysfunction
por: Yu, Dong‐Min, et al.
Publicado: (2017)

CD11b Deficiency Exacerbates Methicillin-Resistant Staphylococcus aureus-Induced Sepsis by Upregulating Inflammatory Responses of Macrophages
por: Sim, Hyunsub, et al.
Publicado: (2021)

Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia
por: Lee, Keunwook, et al.
Publicado: (2012)

C-Reactive Protein Inhibits Survivin Expression via Akt/mTOR Pathway Downregulation by PTEN Expression in Cardiac Myocytes
por: Lee, Beom Seob, et al.
Publicado: (2014)

Acyl-CoA thioesterase 7 is involved in cell cycle progression via regulation of PKCζ–p53–p21 signaling pathway
por: Jung, Seung Hee, et al.
Publicado: (2017)

Prognostic Significance of p53, mTOR, c-Met, IGF-1R, and HSP70 Overexpression after the Resection of Hepatocellular Carcinoma
por: Kang, Gu Hyum, et al.
Publicado: (2014)

Inhibition of the AKT/mTOR pathway negatively regulates PTEN expression via miRNAs: Effect of Akt/mTOR inhibition on PTEN expression
por: Wan, Linyan, et al.
Publicado: (2022)

The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway
por: Korotchkina, Lioubov G., et al.
Publicado: (2010)

Phosphorylated mTOR Expression Profiles in Human Normal and Carcinoma Tissues
por: Lee, Hojung
Publicado: (2017)

Mimulone-Induced Autophagy through p53-Mediated AMPK/mTOR Pathway Increases Caspase-Mediated Apoptotic Cell Death in A549 Human Lung Cancer Cells
por: An, Hyun-Kyu, et al.
Publicado: (2014)

Glucose‐lowering effect of Gryllus bimaculatus powder on streptozotocin‐induced diabetes through the AKT/mTOR pathway
por: Park, Seon‐Ah, et al.
Publicado: (2019)

Dissecting the role of mTOR complexes in cellular senescence
por: Serrano, Manuel
Publicado: (2012)

Decision-making by p53 and mTOR
por: Maki, Carl G.
Publicado: (2010)

Radiation-inducible miR-770-5p sensitizes tumors to radiation through direct targeting of PDZ-binding kinase
por: Lee, Hyung Chul, et al.
Publicado: (2017)

WIG1 is crucial for AGO2-mediated ACOT7 mRNA silencing via miRNA-dependent and -independent mechanisms
por: Lee, Hyung Chul, et al.
Publicado: (2017)

Gomisin G Inhibits the Growth of Triple-Negative Breast Cancer Cells by Suppressing AKT Phosphorylation and Decreasing Cyclin D1
por: Maharjan, Sony, et al.
Publicado: (2018)

Gomisin G Suppresses the Growth of Colon Cancer Cells by Attenuation of AKT Phosphorylation and Arrest of Cell Cycle Progression
por: Maharjan, Sony, et al.
Publicado: (2019)

PS114. Effects of Tianeptine on mTOR Signaling in Rat Hippocampal Neurons
por: Seo, Mi Kyoung, et al.
Publicado: (2016)

Prognostic Significance of mTOR and PTEN in Patients with Esophageal Squamous Cell Carcinoma
por: Lu, Jianjun, et al.
Publicado: (2015)

Effect of Pinoresinol and Vanillic Acid Isolated from Catalpa bignonioides on Mouse Myoblast Proliferation via the Akt/mTOR Signaling Pathway
por: Kim, Seo-Young, et al.
Publicado: (2022)

Reversal of phenotypes of cellular senescence by pan-mTOR inhibition
por: Walters, Hannah E., et al.
Publicado: (2016)

TP53 and MTOR crosstalk to regulate cellular senescence
por: Galluzzi, Lorenzo, et al.
Publicado: (2010)

DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence
por: Leontieva, Olga V., et al.
Publicado: (2010)

Adeno-Associated Viral Vector-Mediated mTOR Inhibition by Short Hairpin RNA Suppresses Laser-Induced Choroidal Neovascularization
por: Park, Tae Kwann, et al.
Publicado: (2017)

Senescent tumor cells in colorectal cancer are characterized by elevated enzymatic activity of complexes 1 and 2 in oxidative phosphorylation
por: Shin, Jun Sang, et al.
Publicado: (2023)

Erratum to “Gomisin G Inhibits the Growth of Triple-Negative Breast Cancer Cells by Suppressing AKT Phosphorylation and Decreasing Cyclin D1” [Biomol.Ther. 26 (2018) 322–327]
por: Maharjan†, Sony, et al.
Publicado: (2018)

mTOR-Mediated Antioxidant Activation in Solid Tumor Radioresistance
por: Woo, Yunseo, et al.
Publicado: (2019)

mTOR-dependent phosphorylation controls TFEB nuclear export
por: Napolitano, Gennaro, et al.
Publicado: (2018)

mTOR inhibition as a novel gene therapeutic strategy for diabetic retinopathy
por: Lee, Steven Hyun Seung, et al.
Publicado: (2022)

Role of PTEN, PI3K, and mTOR in Triple-Negative Breast Cancer
por: Prvanović, Mirjana, et al.
Publicado: (2021)

Targeting mTOR Pathway in PTEN Deleted Newly Isolated Chordoma Cell Line
por: Pagani, Francesca, et al.
Publicado: (2023)

Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish
por: El Maï, Mounir, et al.
Publicado: (2020)

Clinical significance of mTOR, ZEB1, ROCK1 expression in lung tissues of pulmonary fibrosis patients
por: Park, Jong Sun, et al.
Publicado: (2014)

Synergistic Effects of Combination Therapy with AKT and mTOR Inhibitors on Bladder Cancer Cells
por: Kim, Hyera, et al.
Publicado: (2020)

mTOR Activity and Autophagy in Senescent Cells, a Complex Partnership
por: Cayo, Angel, et al.
Publicado: (2021)

Stereoisomer-specific ginsenoside 20(S)-Rg3 reverses replicative senescence of human diploid fibroblasts via Akt-mTOR-Sirtuin signaling
por: Yang, Kyeong-Eun, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_t9bb4tedsfbq6fll0402bqubia