Candidate CSPG4 mutations and induced pluripotent stem cell modeling implicate oligodendrocyte progenitor cell dysfunction in familial schizophrenia

Schizophrenia is highly heritable, yet its underlying pathophysiology remains largely unknown. Among the most well-replicated findings in neurobiological studies of schizophrenia are deficits in myelination and white matter integrity; however, direct etiological genetic and cellular evidence has thu...

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Autores principales: de Vrij, Femke M., Bouwkamp, Christian G., Gunhanlar, Nilhan, Shpak, Guy, Lendemeijer, Bas, Baghdadi, Maarouf, Gopalakrishna, Shreekara, Ghazvini, Mehrnaz, Li, Tracy M., Quadri, Marialuisa, Olgiati, Simone, Breedveld, Guido J., Coesmans, Michiel, Mientjes, Edwin, de Wit, Ton, Verheijen, Frans W., Beverloo, H. Berna, Cohen, Dan, Kok, Rob M., Bakker, P. Roberto, Nijburg, Aviva, Spijker, Annet T., Haffmans, P. M. Judith, Hoencamp, Erik, Bergink, Veerle, Vorstman, Jacob A., Wu, Timothy, Olde Loohuis, Loes M., Amin, Najaf, Langen, Carolyn D., Hofman, Albert, Hoogendijk, Witte J., van Duijn, Cornelia M., Ikram, M. Arfan, Vernooij, Meike W., Tiemeier, Henning, Uitterlinden, André G., Elgersma, Ype, Distel, Ben, Gribnau, Joost, White, Tonya, Bonifati, Vincenzo, Kushner, Steven A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755981/
https://www.ncbi.nlm.nih.gov/pubmed/29302076
http://dx.doi.org/10.1038/s41380-017-0004-2

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