KDM8/JMJD5 as a dual coactivator of AR and PKM2 integrates AR/EZH2 network and tumor metabolism in CRPC

During the evolution into castration or therapy resistance, prostate cancer cells reprogram the androgen responses to cope with the diminishing level of androgens, and undergo metabolic adaption to the nutritionally deprived and hypoxia conditions. AR (androgen receptor) and PKM2 (pyruvate kinase M2...

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Detalles Bibliográficos
Autores principales: Wang, Hung-Jung, Pochampalli, Mamata, Wang, Ling-Yu, Zou, June X, Li, Pei-Shan, Hsu, Sheng-Chieh, Wang, Bi-Juan, Huang, Shih-Han, Yang, Ping, Yang, Joy C., Chu, Cheng-Ying, Hsieh, Chia-Ling, Sung, Shian-Ying, Li, Chien-Feng, Tepper, Clifford G., Ann, David K., Gao, Allen C., Evans, Christopher P., Izumiya, Yoshihiro, Chuu, Chi-Pin, Wang, Wen-Ching, Chen, Hong-Wu, Kung, Hsing-Jien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755995/
https://www.ncbi.nlm.nih.gov/pubmed/30072740
http://dx.doi.org/10.1038/s41388-018-0414-x

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