The coordinated action of VCP/p97 and GCN2 regulates cancer cell metabolism and proteostasis during nutrient limitation

VCP/p97 regulates numerous cellular functions by mediating protein degradation through its segregase activity. Its key role in governing protein homoeostasis has made VCP/p97 an appealing anticancer drug target. Here, we provide evidence that VCP/p97 acts as a regulator of cellular metabolism. We fo...

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Detalles Bibliográficos
Autores principales: Parzych, Katarzyna, Saavedra-García, Paula, Valbuena, Gabriel N., Al-Sadah, Hibah A., Robinson, Mark E., Penfold, Lucy, Kuzeva, Desislava M., Ruiz-Tellez, Angie, Loaiza, Sandra, Holzmann, Viktoria, Caputo, Valentina, Johnson, David C., Kaiser, Martin F., Karadimitris, Anastasios, Lam, Eric W-F, Chevet, Eric, Feldhahn, Niklas, Keun, Hector C., Auner, Holger W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756015/
https://www.ncbi.nlm.nih.gov/pubmed/30626938
http://dx.doi.org/10.1038/s41388-018-0651-z

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