Sumoylation of Flotillin-1 promotes EMT in metastatic prostate cancer by suppressing Snail degradation

Flotillin-1 (Flot-1) has been shown to regulate cancer progression, but the regulatory role of post-translational modifications of Flot-1 on cancers remains elusive. Herein, we show that up-regulated E2 conjugating enzyme UBC9 sumoylates Flot-1 at Lys-51 and Lys-195 with small ubiquitin-like modifie...

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Detalles Bibliográficos
Autores principales: Jang, Donghwan, Kwon, Hayeong, Choi, Moonjeong, Lee, Jaewoong, Pak, Yunbae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756018/
https://www.ncbi.nlm.nih.gov/pubmed/30631151
http://dx.doi.org/10.1038/s41388-018-0641-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756018/
https://www.ncbi.nlm.nih.gov/pubmed/30631151
http://dx.doi.org/10.1038/s41388-018-0641-1

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