SH2B3 inactivation through CN-LOH 12q is uniquely associated with B-cell precursor ALL with iAMP21 or other chromosome 21 gain

In more than 30% of B-cell precursor acute lymphoblastic leukaemia (B-ALL), chromosome 21 sequence is overrepresented through aneuploidy or structural rearrangements, exemplified by intrachromosomal amplification of chromosome 21 (iAMP21). Although frequent, the mechanisms by which these abnormaliti...

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Detalles Bibliográficos
Autores principales: Sinclair, Paul B., Ryan, Sarra, Bashton, Matthew, Hollern, Shaun, Hanna, Rebecca, Case, Marian, Schwalbe, Edward C., Schwab, Claire J., Cranston, Ruth E., Young, Brian D., Irving, Julie A. E., Vora, Ajay J., Moorman, Anthony V., Harrison, Christine J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756024/
https://www.ncbi.nlm.nih.gov/pubmed/30816328
http://dx.doi.org/10.1038/s41375-019-0412-1

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