Constitutively active MyD88/CD40 costimulation enhances expansion and efficacy of chimeric antigen receptor T cells targeting hematological malignancies

Successful adoptive chimeric antigen receptor (CAR) T-cell therapies against hematological malignancies require CAR-T expansion and durable persistence following infusion. Balancing increased CAR-T potency with safety, including severe cytokine-release syndrome (sCRS) and neurotoxicity, warrants inc...

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Detalles Bibliográficos
Autores principales: Collinson-Pautz, Matthew R., Chang, Wei-Chun, Lu, An, Khalil, Mariam, Crisostomo, Jeannette W., Lin, Pei-Yi, Mahendravada, Aruna, Shinners, Nicholas P., Brandt, Mary E., Zhang, Ming, Duong, MyLinh, Bayle, J. Henri, Slawin, Kevin M., Spencer, David M., Foster, Aaron E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756044/
https://www.ncbi.nlm.nih.gov/pubmed/30816327
http://dx.doi.org/10.1038/s41375-019-0417-9

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