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PKNOX2 suppresses gastric cancer through the transcriptional activation of IGFBP5 and p53

Promoter methylation plays a vital role in tumorigenesis through transcriptional silencing of tumor suppressive genes. Using genome-wide methylation array, we first identified PBX/Knotted Homeobox 2 (PKNOX2) as a candidate tumor suppressor in gastric cancer. PKNOX2 mRNA expression is largely silence...

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Detalles Bibliográficos
Autores principales:	Zhang, Li, Li, Weilin, Cao, Lei, Xu, Jiaying, Qian, Yun, Chen, Huarong, Zhang, Yanquan, Kang, Wei, Gou, Hongyan, Wong, Chi Chun, Yu, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756047/ https://www.ncbi.nlm.nih.gov/pubmed/30745575 http://dx.doi.org/10.1038/s41388-019-0743-4

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