AKT inhibition impairs PCNA ubiquitylation and triggers synthetic lethality in homologous recombination-deficient cells submitted to replication stress

Translesion DNA synthesis (TLS) and homologous recombination (HR) cooperate during S-phase to safeguard replication forks integrity. Thus, the inhibition of TLS becomes a promising point of therapeutic intervention in HR-deficient cancers, where TLS impairment might trigger synthetic lethality (SL)....

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Detalles Bibliográficos
Autores principales: Villafañez, Florencia, García, Iris Alejandra, Carbajosa, Sofia, Pansa, María Florencia, Mansilla, Sabrina, Llorens, María Candelaria, Angiolini, Virginia, Guantay, Laura, Jacobs, Heinz, Madauss, Kevin P., Gloger, Israel, Gottifredi, Vanesa, Bocco, Jose Luis, Soria, Gaston
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756059/
https://www.ncbi.nlm.nih.gov/pubmed/30705406
http://dx.doi.org/10.1038/s41388-019-0724-7

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