Inhibitory effects of midostaurin and avapritinib on myeloid progenitors derived from patients with KIT D816V positive advanced systemic mastocytosis

Advanced systemic mastocytosis (advSM) is characterized by the presence of an acquired KIT D816V mutation in >90% of patients. In the majority of patients, KIT D816V is not only detected in mast cells but also in other hematopoietic lineages. We sought to investigate the effects of the KIT-inhibi...

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Detalles Bibliográficos
Autores principales: Lübke, Johannes, Naumann, Nicole, Kluger, Sebastian, Schwaab, Juliana, Metzgeroth, Georgia, Evans, Erica, Gardino, Alexandra K., Lengauer, Christoph, Hofmann, Wolf-Karsten, Fabarius, Alice, Cross, Nicholas C. P., Reiter, Andreas, Jawhar, Mohamad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756065/
https://www.ncbi.nlm.nih.gov/pubmed/30911112
http://dx.doi.org/10.1038/s41375-019-0450-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756065/
https://www.ncbi.nlm.nih.gov/pubmed/30911112
http://dx.doi.org/10.1038/s41375-019-0450-8

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