mTORC2-mediated PDHE1α nuclear translocation links EBV-LMP1 reprogrammed glucose metabolism to cancer metastasis in nasopharyngeal carcinoma

EBV infection of preinvasive nasopharyngeal epithelium is believed to be an initiation step during pathogenesis of nasopharyngeal carcinoma (NPC), but the mechanisms remain poorly understood. Here we report a novel mechanism driving NPC metastasis through the EBV-encoded LMP1-mediated metabolic repr...

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Detalles Bibliográficos
Autores principales: Zhang, Jun, Jia, Lin, Liu, Tengfei, Yip, Yim Ling, Tang, Wing Chung, Lin, Weitao, Deng, Wen, Lo, Kwok Wai, You, Chanping, Lung, Maria Li, Lung, Hong Lok, Cheung, Annie Lai-Man, Tsao, Sai Wah, Tsang, Chi Man
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756087/
https://www.ncbi.nlm.nih.gov/pubmed/30745576
http://dx.doi.org/10.1038/s41388-019-0749-y

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