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Gamma-secretase-dependent signaling of receptor tyrosine kinases

Human genome harbors 55 receptor tyrosine kinases (RTK). At least half of the RTKs have been reported to be cleaved by gamma-secretase-mediated regulated intramembrane proteolysis. The two-step process involves releasing the RTK ectodomain to the extracellular space by proteolytic cleavage called sh...

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Detalles Bibliográficos
Autores principales:	Merilahti, Johannes A.M., Elenius, Klaus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756091/ https://www.ncbi.nlm.nih.gov/pubmed/30166589 http://dx.doi.org/10.1038/s41388-018-0465-z

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