Lysosomal trapping of palbociclib and its functional implications

Palbociclib is a selective inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6) approved for the treatment of some cancers. The main mechanism of action of palbociclib is to induce cell cycle arrest and senescence on responsive cells. Here, we report that palbociclib concentrates in intracellular...

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Detalles Bibliográficos
Autores principales: Llanos, Susana, Megias, Diego, Blanco-Aparicio, Carmen, Hernández-Encinas, Elena, Rovira, Miguel, Pietrocola, Federico, Serrano, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756094/
https://www.ncbi.nlm.nih.gov/pubmed/30692638
http://dx.doi.org/10.1038/s41388-019-0695-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756094/
https://www.ncbi.nlm.nih.gov/pubmed/30692638
http://dx.doi.org/10.1038/s41388-019-0695-8

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