Unbalanced YAP–SOX9 circuit drives stemness and malignant progression in esophageal squamous cell carcinoma

Yes-associated protein (YAP) has been identified as a key regulator of tissue homeostasis. However, the precise role and regulatory mechanism of YAP in esophageal squamous cell carcinoma (ESCC) remains unclear. Here we report that the genetic or pharmacological inhibition of YAP repressed cancer ste...

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Detalles Bibliográficos
Autores principales: Wang, Lianghai, Zhang, Zhiyu, Yu, Xiaodan, Huang, Xuan, Liu, Zheng, Chai, Yuhang, Yang, Lei, Wang, Qian, Li, Man, Zhao, Jin, Hou, Jun, Li, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756096/
https://www.ncbi.nlm.nih.gov/pubmed/30401982
http://dx.doi.org/10.1038/s41388-018-0476-9

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