Cross-species genomics identifies DLG2 as a tumor suppressor in osteosarcoma

Leveraging the conserved cancer genomes across mammals has the potential to transform driver gene discovery in orphan cancers. Here, we combine cross-species genomics with validation across human–dog–mouse systems to uncover a new bone tumor suppressor gene. Comparative genomics of spontaneous human...

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Detalles Bibliográficos
Autores principales: Shao, Yang W., Wood, Geoffrey A., Lu, Jinchang, Tang, Qing-Lian, Liu, Jonathan, Molyneux, Sam, Chen, Yan, Fang, Hui, Adissu, Hibret, McKee, Trevor, Waterhouse, Paul, Khokha, Rama
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756098/
https://www.ncbi.nlm.nih.gov/pubmed/30093633
http://dx.doi.org/10.1038/s41388-018-0444-4

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