Forcing ATGL expression in hepatocarcinoma cells imposes glycolytic rewiring through PPAR-α/p300-mediated acetylation of p53

Metabolic reprogramming is a typical feature of cancer cells aimed at sustaining high-energetic demand and proliferation rate. Here, we report clear-cut evidence for decreased expression of the adipose triglyceride lipase (ATGL), the first and rate-limiting enzyme of triglyceride hydrolysis, in both...

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Detalles Bibliográficos
Autores principales: Di Leo, Luca, Vegliante, Rolando, Ciccarone, Fabio, Salvatori, Illari, Scimeca, Manuel, Bonanno, Elena, Sagnotta, Andrea, Grazi, Gian Luca, Aquilano, Katia, Ciriolo, Maria Rosa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756110/
https://www.ncbi.nlm.nih.gov/pubmed/30367149
http://dx.doi.org/10.1038/s41388-018-0545-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756110/
https://www.ncbi.nlm.nih.gov/pubmed/30367149
http://dx.doi.org/10.1038/s41388-018-0545-0

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