The P2X7 receptor modulates immune cells infiltration, ectonucleotidases expression and extracellular ATP levels in the tumor microenvironment

In the tumor microenvironment (TME) ATP and its receptor P2X7 exert a pivotal influence on cancer growth and tumor–host interactions. Here we analyzed the different effect of P2X7 genetic deficiency versus its antagonism on response against P2X7-expressing implanted tumors. We focused on immune cell...

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Detalles Bibliográficos
Autores principales: De Marchi, Elena, Orioli, Elisa, Pegoraro, Anna, Sangaletti, Sabina, Portararo, Paola, Curti, Antonio, Colombo, Mario Paolo, Di Virgilio, Francesco, Adinolfi, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756114/
https://www.ncbi.nlm.nih.gov/pubmed/30655604
http://dx.doi.org/10.1038/s41388-019-0684-y

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