Rare, functional, somatic variants in gene families linked to cancer genes: GPCR signaling as a paradigm

Oncodriver genes are usually identified when mutations recur in multiple tumours. Different drivers often converge in the activation or repression of key cancer-relevant pathways. However, as many pathways contain multiple members of the same gene family, individual mutations might be overlooked, as...

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Detalles Bibliográficos
Autores principales: Raimondi, Francesco, Inoue, Asuka, Kadji, Francois M. N., Shuai, Ni, Gonzalez, Juan-Carlos, Singh, Gurdeep, de la Vega, Alicia Alonso, Sotillo, Rocio, Fischer, Bernd, Aoki, Junken, Gutkind, J. Silvio, Russell, Robert B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756116/
https://www.ncbi.nlm.nih.gov/pubmed/31337866
http://dx.doi.org/10.1038/s41388-019-0895-2

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