Addiction to DUSP1 protects JAK2V617F-driven polycythemia vera progenitors against inflammatory stress and DNA damage, allowing chronic proliferation

Inflammatory and oncogenic signaling converge in disease evolution of BCR–ABL-negative myeloproliferative neoplasms, clonal hematopoietic stem cell disorders characterized by gain-of-function mutation in JAK2 kinase (JAK2V617F), with highest prevalence in patients with polycythemia vera (PV). Despit...

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Detalles Bibliográficos
Autores principales: Stetka, J., Vyhlidalova, P., Lanikova, L., Koralkova, P., Gursky, J., Hlusi, A., Flodr, P., Hubackova, S., Bartek, J., Hodny, Z., Divoky, V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756199/
https://www.ncbi.nlm.nih.gov/pubmed/30967632
http://dx.doi.org/10.1038/s41388-019-0813-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756199/
https://www.ncbi.nlm.nih.gov/pubmed/30967632
http://dx.doi.org/10.1038/s41388-019-0813-7

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